Research Topics

  • Optical Chemo- and Biosensors
  • Nano and micrometer sized (magnetic) sensor particles
  • Optical glucose sensors
  • New indicator dyes for optical sensing
  • Optical multi-analyte sensors
  • Integrated optical sensors based on organic optoelectronic components
  • Time-resolved imaging and microscopy with lumincescent indicators
  • Microfluidic devices / Lab on Chip with integrated optical sensors

Research projects - ongoing

EU-FP 7: SCHeMA - Integrated In Situ Chemical MApping Probes

SCHeMA aims at providing an open and modular sensing solution for in situ high resolution mapping of a range of anthropogenic and natural chemical compounds that may have feedback (synergic) interaction: toxic and/or essential Hg, Cd, Pb, As and Cu trace metal species; nitrate, nitrite, and phosphate nutrients; species relevant to the carbon cycle; volatile organic compounds; potentially toxic algae species and toxins.

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EU-FP 7: SenseOCEAN - SenseOcean:Marine sensors for the 21st Century

senseOCEAN brings together the leading sensor developers from academia and industry across Europe to enable a quantum leap in worldwide in situ ocean biogeochemical sensor technology. It will produce fundamental innovations in analytical sciences fusing together new techniques for microfabrication, system integration, self calibration and cost-effective mass production.

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ERC: OXYGEN - How oxygen regulates the structure and function of microbial ecosystems

Our aim is to develop and use cutting-edge high-sensitivity oxygen detection systems to explore how oxygen regulates the metabolism of aerobic and anaerobic organisms in experimental systems and in nature. We will explore and understand the complex structure of low oxygen ecosystems on the present Earth, and the evolution of these ecosystems through time in the face of changing concentrations of atmospheric oxygen.

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CHEBANA - Chemical Bioanalysis

Chemical Bioanalysis aims for retrieving selective information out of complex biological systems. Sensors, probes and devices are the future tools of medicinal diagnostics, environmental monitoring, food analysis and molecular biology.

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Research projects - completed

Indicators for long-wave excitable luminescent sensors

The project is focused on designing luminescent sensors which can be interrogated with long-wave emitting light sources. To realize this, novel red-light excitable oxygen indicators and fluorescent pH indicators are synthesized and characterized.

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Optical ammonia sensors with detection limits in the ppb range

Sensitive and selective sensor materials for on-line monitoring of gaseous and dissolved ammonia are developed in this research project. The survey of the ammonia concentration in drinking and surface waters for environmental analysis, fish farms.

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Database of fluorescent dyes, properties and application

The objective of Fluorophores.org is to provide an accurate, high valuable and comprehensive catalogue of fluorescent (luminescent) dyes, their properties and application. The initiators intend to create a usefull tool for scientists working with fluorescence.

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ISOTEC- Integrated organic optical sensor arrays

The research project, as a part of the ISOTEC Cluster project, established an integrated organic optical sensor platform suitable for the parallel detection of multiple parameters in an array format.

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Nano- and microsensors for the application in biofilms

Due to the ubiquity of biofilms in nature it is of great interest to understand their metabolism and the interaction of the different parts and organisms inside a biofilm. For this porpous optical thinlayer and nano sensors are used to investigate the oxygenation and other parameters with high spatial resolution on the surface or even within the biofilm itself.

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Lise Meitner-Program: Optical multi-analyte sensors

This project is aimed to realize optical multy-analyte sensors that are capable of simultaneous measurement of 4 parameters. Three chemical parameters (pH, pO2 and pCO2/pNH3/salinity) are determined and combined with optical compensation for the temperature effects.

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Closed Loop Insulin Infusion for Critically Ill Patients

The research group is envolved in this EU project of 6th Framework Programme. In breave, Clinicip has the aim to develop a low-risk monitoring and control system which allows to maintain metabolic control of critically ill patients in the intensive care unit.

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Sugar responsive fluorescent nanospheres

In this research project we develop sugar responsive nanosensors based on the osmotic presure driven swelling of an amphiphilic polymer. The volume transition is tracked by resonance energy transfer (RET) of co-polymerized donor and acceptor dyes.

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Microsphere Sedimentation Bioarrays

A new measurement platform to analyze multiple assays in parallel in a single well of a standard microplate is developed..The approach is based on optically addressable encoded magnetic microbeads as carriers for a series of bioassays.

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Screening of Microcolony chip with optical sensor layers

Directed evolution has become a widely used technique in enzyme development. It leads often to vast libraries of potential new variants which have to be examined. High throughput methods offer the possibility to examine huge amounts of sample in parallel.

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